Gene encoding syntaxin interacting protein

Details Gene encoding syntaxin interacting protein Gene encoding syntaxin interacting protein

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 16/18 (2006.01) C07K 16/28 (2006.01) C12N 15/10 (2006.01) C12P 21/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2326623

The present invention relates to novel genes and polypeptides derived therefrom encoding a syntaxin interacting protein. The invention also describes vectors and host cells comprising the novel gene. The invention further describes methods for using the novel gene, polypeptides, and antibodies specifically targeting polypeptides derived from the novel genes, in the detection of genetic deletions of the gene, subcellular localization of the polypeptide, isolation of discrete classes of RNA, gene therapy applications, diagnostics for syndromes involving insulin resistance, development of proprietary screening strategies for inhibitors of syntaxin interacting protein.

L'invention concerne de nouveaux gènes et des polypeptides dérivés codant pour une protéine interagissant avec une syntaxine. L'invention concerne également des vecteurs et des cellules hôtes comprenant ce nouveau gène, ainsi que des procédés d'utilisation du nouveau gène, des polypeptides et des anticorps ciblant spécifiquement les polypeptides dérivés de ces nouveaux gènes. Ces procédés permettent la détection de déficiences génétiques, la localisation sous-cellulaire du polypeptide, l'isolement de classes distinctes d'ARN, l'application de thérapies géniques, les diagnostics pour les syndromes faisant intervenir la résistance à l'insuline, la mise au point de stratégies de criblage de spécialités pour des inhibiteurs de la protéine interagissant avec la syntaxine.

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