Method of promoting bone growth with hyaluronic acid and...

A - Human Necessities – 61 – K

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Details

A61K 31/715 (2006.01) A61K 31/728 (2006.01) A61K 38/00 (2006.01) A61K 38/18 (2006.01)

Patent

CA 2378328

A bone growth-promoting composition is provided comprising hyaluronic acid and a growth factor. The composition has a viscosity and biodegradability sufficient to persist at an intra-articular site of desired bone growth for a period of time sufficient to promote the bone growth. Preferably hyaluronic acid is used in a composition range of 0.1-4 % by weight and preferred growth factor is bFGF, present in a concentration range of about 10-6 to 100 mg/ml.

L'invention concerne une composition servant à favoriser la croissance osseuse comprenant un acide hyaluronique et un facteur de croissance. Ladite composition présente une viscosité et un caractère biodégradable qui suffisent pour perdurer au niveau d'un site intra-articulaire de croissance osseuse souhaitée pour une période de temps suffisant pour favoriser la croissance osseuse. On utilise, de préférence, un acide hyaluronique dans une gamme de composition de 0,1 à 4 % en poids et le facteur de croissance est bFGF, présent dans une gamme de concentration d'environ 10?-6¿ à 100 mg/ml.

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