Piperidyindoles as serotonin receptor ligands

Details Piperidyindoles as serotonin receptor ligands Piperidyindoles as serotonin receptor ligands

C - Chemistry, Metallurgy

07

D

C07D 417/14 (2006.01) A61K 31/445 (2006.01) A61K 31/475 (2006.01) A61K 31/54 (2006.01) A61P 25/00 (2006.01) C07D 401/14 (2006.01)

Patent

CA 2410091

A pharmaceutical compound of the formula (I) in which R1 and R2 are each hydrogen or C1-6 alkyl, R3 is -SR10, -SOR10, -SO2R10, -COR10, -CH2OH or - CONHR11, where R10 is C1-6 alkyl and R11 is hydrogen or C1-6 alkyl, R4, R5, R6 and R7 are each hydrogen or C1-6 alkyl, provided that at least one of R4, R5, R6 and R7 is C1-6 alkyl, R8 and R9 are each hydrogen, halo, C1-6 alkyl or cyano, n is 0 or 1 and m is 2 or 3, x is a (a) or (b), and y is (c) or (d), wherein R12 and R13 are each hydrogen, C1- alkyl, cyclopropyl or cyclopropyl- C1-6 alkyl; and salts thereof.

L'invention concerne un composé pharmaceutique représenté par la formule (I) dans laquelle R?1¿ et R?2¿ représentent chacun hydrogène ou alkyle C¿1-6?, R?3¿ représente SR?10¿, -SOR?10¿, -SO¿2?R?10¿, -COR?10¿, -CH¿2?OH ou -CONHR?11¿, où R?10¿ représente alkyle C¿1-6? et R?11¿ représente hydrogène ou alkyle C¿1-6?, R?4¿, R?5¿, R?6¿ et R?7¿ représentent chacun hydrogène ou alkyle C¿1-6?, à la condition qu'au moins un parmi R?4¿, R?5¿, R?6¿ et R?7¿ représente alkyle C¿1-6?, R?8¿ et R?9¿ représentent chacun hydrogène, halo, alkyle C¿1-6? ou cyano, n vaut 0 ou 1 et m vaut 2 ou 3,x est (a) ou (b), et y est (c) (d), où R?12¿ et R?13¿ représentent chacun hydrogène, alkyle C1-6, cyclopropyle ou cyclopropyle-alkyle C¿1-6?. L'invention concerne également des sels de ce composé.

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