Methods for preventing, postponing or improving the outcome...

A - Human Necessities – 61 – K

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A61K 39/395 (2006.01) A61K 38/16 (2006.01) A61K 45/00 (2006.01) A61P 19/04 (2006.01)

Patent

CA 2692428

Methods for identifying subjects who could benefit therapeutically from administration of a targeted anti-inflamma-tory therapy (TAT) are provided. Subjects that are identified include those that are eligible, based on pre-determined criteria, for a spinal surgery procedure, such as a laminectomy or diskectomy. Methods of preventing such procedures or improving the outcome of such procedures are also provided, and include administering a TAT to the subject by any route or regimen of administration, including both known and novel regimens described herein.

L'invention concerne des procédés pour identifier des patients qui pourraient bénéficier thérapeutiquement de l'administration d'une thérapie anti-inflammatoire ciblée (TAT). Les sujets identifiés comprennent ceux qui peuvent faire l'objet, sur base d'un critère prédéterminé, d'une opération chirurgicale de la colonne vertébrale, par exemple une laminectomie ou une discectomie. L'invention concerne également des procédés pour éviter ces opérations ou pour améliorer le résultat de ces opérations, qui concernent l'administration d'une TAT au sujet par n'importe quel voie ou régime d'administration, y compris les régimes connus et nouveaux décrits ici.

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