Methods for inhibiting bone loss

Details Methods for inhibiting bone loss Methods for inhibiting bone loss

A - Human Necessities

61

K

A61K 31/54 (2006.01) A61K 31/38 (2006.01) A61K 31/40 (2006.01) A61K 31/445 (2006.01) A61K 31/47 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01)

Patent

CA 2117854

ABSTRACT A method of inhibiting bone loss comprising administering to a human in need of treatment an effective amount of a compound having the formula (I) Image wherein R is hydrogen; hydroxy; C1-C6 alkoxy; a group of the formula -O-C(O)-Ra, wherein Ra is hydrogen, C1-C6 alkyl optionally substituted with amino, halo, carbonyl, C1-C6 alkoxycarbonyl, C1-C7 alkanoyloxy, carbamoyl and/or aryl; or Ra is C1-C6 alkenyl optionally substituted with aryl; or Ra is a C3-C7 cycloalkyl; or Ra is aryl optionally substituted with hydroxy, C1-C6 alkyl, C1-C6 alkoxy, and/or halo; or Ra is -O-aryl, said aryl optionally substituted with hydroxy C1-C6 alkyl, C1- C6 alkoxy, and/or halo, or R is a group of the formula -O-SO2-Rb wherein Rb may be C1-C6 alkyl or aryl optionally substituted with C1-C6 alkyl; or R is carbamoyloxy wherein the nitrogen may be substituted once or twice with C1-C6 alkyl; or R is a group of the formula -O-C(O)RC-O- (C1-C6 alkyl) wherein Rc is a bond or C1-C6 alkanediyl; R1 is halo, C1-C6 alkyl, C1-C7 alkyl substituted with C1-C6 alkyl, substituted or unsubstituted C3-C7 cycloalkyl, or substituted or unsubstituted C3-C7 cycloalkenyl; R2 is O or CH2; R3 is CH2 or (CH2)2; R4 is Image , CH2, or a bond; and R5 is amino, nitrilo optionally substituted once or twice with C1-C6 alkyl; or an N-heterocyclic ring which optionally has another hetero atom selected from N, O, or S in said ring; or a pharmaceutically acceptable salt or solvate thereof.

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