C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/12 (2006.01) A61K 31/415 (2006.01) A61K 31/4375 (2006.01) A61K 31/4725 (2006.01) A61P 3/04 (2006.01) C07D 231/38 (2006.01) C07D 401/12 (2006.01) C07D 403/14 (2006.01) C07D 471/04 (2006.01)
Patent
CA 2657660
Certain novel N-acylated spiropiperidine derivatives are ligands of the human ghrelin receptor(s) and, in particular, are antagonists/inverse agonists of the human ghrelin receptor. They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the modulation of the ghrelin receptor, such as obesity, diabetes, and metabolic syndrome.
Selon l'invention, certains nouveaux dérivés de la spiropipéridine acylés en N sont des ligands du ou des récepteurs humains de la ghréline et, en particulier, ils sont des antagonistes/agonistes inverses du récepteur humain de la ghréline. Ils sont par conséquent utiles pour le traitement, le contrôle ou la prévention de maladies et de troubles sensibles à la modulation du récepteur de la ghréline, tels que l'obésité, le diabète et un syndrome métabolique.
Cline Eric
Ge Min
Mills Sander G.
Yang Lihu
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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