Use of cell membrane permeants in the treatment of cellular...

Details Use of cell membrane permeants in the treatment of cellular... Use of cell membrane permeants in the treatment of cellular...

A - Human Necessities

61

K

A61K 47/28 (2006.01) A61K 31/475 (2006.01) A61K 31/70 (2006.01) A61K 38/19 (2006.01) A61K 45/08 (2006.01) A61K 47/42 (2006.01) A61K 47/46 (2006.01)

Patent

CA 2247481

Methods are provided for the treatment of a host suffering from a cellular proliferative disease through administration of a chemotherapeutic agent in conjunction with a cell membrane permeant. Optionally, the cell membrane permeant and/or chemotherapeutic agent will be present in a pharmaceutically acceptable vehicle capable of acting as a depot. In the subject methods, the chemotherapeutic agent and membrane permeant are administered at least proximal to a target site of the host. Administration of chemotherapeutic agents in accordance with the subject methods results in improved efficacy of, and/or decreased host toxicity to, the intralesionally administered chemotherapeutic agent.

Méthode de traitement d'un sujet souffrant d'une maladie cellulaire proliférative par administration d'un agent chimiothérapeutique en conjonction avec un perméant de membrane cellulaire. Facultativement, ce perméant de membrane cellulaire et/ou cet agent chimiothérapeutique sont présents dans un vecteur pharmaceutiquement acceptable pouvant agir comme un dépôt. Selon les méthodes visées ici, l'agent chimiothérapeutique et le perméant de membrane sont administrés au moins à proximité d'un site cible chez le patient. L'administration d'agents chimiothérapeutiques selon les méthodes en question apporte un gain d'efficacité et/ou une diminution de la toxicité pour le patient de l'agent chimiothérapeutique administré à l'intérieur des lésions.

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