A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/165 (2006.01) A61K 9/70 (2006.01) A61P 25/02 (2006.01)
Patent
CA 2517493
Topical patch containing capsaicin or a capsaicin analog, process for its preparation and its use. The invention relates to a topical patch comprising a therapeutic compound-impermeable backing layer, a self-adhesive matrix based on polysiloxanes and containing capsaicin or a therapeutic compound analogous to capsaicin, and a protective film to be removed before use, in which the matrix contains liquid microreservoirs based on an amphiphilic solvent, in which the therapeutic compound is present in completely dissolved form and the concentration of the therapeutic compound in the microreservoir droplets is below the saturation concentration. The invention furthermore relates to a process for its production and its use in the treatment of neuropathic pain.
L'invention concerne un dispositif transdermique topique contenant de la capsaicine ou un analogue de la capsaicine, son procédé de production et son utilisation. L'invention concerne un dispositif transdermique topique comprenant une couche support imperméable au composé thérapeutique, une matrice autocollante à base de polysiloxanes et contenant de la capsaicine ou un composé thérapeutique analogue à la capsaicine, et un film protecteur à retirer avant utilisation. La matrice contient des microréservoirs de liquide à base d'un solvant amphiphile. Le composé thérapeutique est présent sous forme complètement dissoute et la concentration du composé thérapeutique dans les gouttelettes microréservoirs est inférieure à la concentration de saturation. L'invention concerne également son procédé de production et son utilisation dans le traitement de douleurs neuropathiques.
Fetherstonhaugh & Co.
Lts Lohmann Therapie-Systeme Ag
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