Methods to treat autoimmune and inflammatory conditions

A - Human Necessities – 61 – K

Patent

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Details

IPC codes

A61K 31/675 (2006.01) A61K 31/513 (2006.01) A61K 31/519 (2006.01) A61K 31/7068 (2006.01) A61K 31/7072 (2006.01)

Type

Patent

Patent number

CA 2441350

Description

This invention provides methods for treating inflammatory or autoimmune diseases by contacting the affected cell or tissue with a therapeutic compound as described herein. Such pathologies include, but are not limited to rheumatoid arthritis, systemic lupus erythmatosus, psoriatic arthritis, reactive arthritis, Crohn's disease, ulcerative colitis and scleroderma. Therapeutic compounds useful in the methods of this invention are selected from the group consisting of a 1,5-substituted pyrimidine derivative or analog and substituted furano-pyrimidone analog.

L'invention concerne des procédés relatifs au traitement des maladies inflammatoires ou auto-immunes, qui consistent à mettre en contact les cellules ou les tissus affectés avec le type de composé thérapeutique décrit. Sans exhaustivité, on peut citer les états pathologiques suivants: polyarthrite rhumatoïde, lupus érythémateux disséminé, arthrite psoriasique, arthrite réactionnelle, maladie de Chron, colite ulcéreuse et sclérodermie. Les composés thérapeutiques utiles dans le cadre des procédés considérés appartiennent au groupe comprenant: dérivé ou analogue de pyrimidine à substitution en 1,5, et analogue de furano-pyrimidone à substitution.

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