Method of enhancing nutrient uptake

A - Human Necessities – 61 – K

Patent

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Details

A61K 38/22 (2006.01) A61K 45/00 (2006.01) C07K 14/575 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2211842

Methods using Peptide YY (PYY) receptor agonists to increase absorption of nutrients from the intestine without a concomitant increase in intestinal energy expenditure. The methods comprise administering PYY peptide or PYY peptide agonists to subjects. Methods using Peptide YY (PYY) antagonists to decrease absorption of nutrients from the intestine. The methods comprise administering PYY receptor antagonists to subjects. Pharmaceutical formulations comprising PYY receptor agonists, such as the PYY peptide and analogs thereof, and pharmaceutical formulation comprising PYY antagonists.

L'invention concerne des procédés dans lesquels on utilise des agonistes du récepteur du peptide YY (PYY) afin d'améliorer l'absorption de substances nutritives par l'intestin sans augmenter simultanément la dépense d'énergie de l'intestin. Ces procédés consistent à administrer le peptide PYY ou des agonistes du peptide PYY à un sujet. L'invention porte aussi sur des procédés dans lesquels on utilise des antagonistes du peptide YY (PYY) afin de diminuer l'absorption de substances nutritives par l'intestin. Ces procédés consistent à administrer des antagonistes du récepteur de PYY à un sujet. L'invention se rapporte encore à des compositions pharmaceutiques comprenant des agonistes du récepteur de PYY, tels que le peptide PYY et ses analogues, et à des compositions pharmaceutiques comprenant des antagonistes de PYY.

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