A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/22 (2006.01) A61K 9/16 (2006.01) A61K 9/20 (2006.01) A61K 9/36 (2006.01) A61K 31/196 (2006.01) A61K 31/341 (2006.01) A61K 31/64 (2006.01) A61K 9/28 (2006.01)
Patent
CA 2476050
A sustained/controlled release formulation with reduced risk of dose dumping and side effects combines two components: component (a) comprises a pharmaceutically active agent and a water-insoluble, but water-permeable polymer, whereas component (b) comprises a pharmaceutically active agent and a hydrophobic material. By changing the ratio of a pharmaceutically active agent and water-insoluble, but water-permeable polymer comprised in the component (a) and/or the ratio of the pharmaceutically active agent and hydrophobic material comprised in the component (b), an ideal release rate, with reduced risk of dose dumping and side effects, can easily be achieved.
Une formulation à libération prolongée/contrôlée présentant un risque faible de libération massive et d'effets secondaires associe deux constituants: un constituant (a) comprend un agent pharmaceutiquement actif et un polymère insoluble dans l'eau mais perméable à l'eau, un constituant (b) comprend un agent pharmaceutiquement actif et une matière hydrophobe. Par changement du rapport entre un agent pharmaceutiquement actif et un polymère insoluble dans l'eau mais perméable à l'eau contenu dans le constituant (a), et/ou du rapport entre l'agent pharmaceutiquement actif et la matière hydrophobe contenue dans le constituant (b), on peut obtenir facilement un taux de libération idéal avec un risque réduit de libération massive et d'effets secondaires.
Khan M. Zahirul I.
Knezevic Zdravka
Krajacic Aleksandra
Vodopija-Mandic Snjezana
Borden Ladner Gervais Llp
Khan M. Zahirul I.
Knezevic Zdravka
Krajacic Aleksandra
Pliva-Istrazivacki Institut D.o.o.
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