Pyrimidine compounds for treating gpr119 related disorders

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 401/12 (2006.01) A61K 31/506 (2006.01) A61P 3/00 (2006.01) C07D 401/14 (2006.01)

Patent

CA 2661371

The present invention relates to compounds of Formula (1a) and pharmaceutically acceptable salts, hydrates, geometrical isomers, racemates, tautomers, optical isomers and N-oxides thereof, wherein W1 and W3 are N and W and W4 are CR12, or W1 and W3 are CR12 and W2 and W4 are N. The invention also relates to pharmaceutical compositions comprising these compounds, and to the use of these compounds for the prophylaxis and treatment of medical conditions relating to disorders of the G-protein-coupled receptor GPR119, such as diabetes and obesity.

L'invention concerne des composés de formule (1a) et leurs sels, hydrates, isomères géométriques, racémates, tautomères, isomères optique et N-oxydes pharmaceutiquement acceptables, W1et W3 représentant N, et W et W4 représentant CR12, ou W1 et W3 représentant CR12 et W2 et W4 représentant N. L'invention concerne également des compositions pharmaceutiques renfermant lesdits composés et l'utilisation desdits composés pour la prophylaxie et le traitement de pathologies médicales relatives à des troubles du récepteur de GPR119 couplé à la protéine G, tels que le diabète et l'obésité.

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