Methods to determine if a subject will respond to a bcr-abl...

Details Methods to determine if a subject will respond to a bcr-abl... Methods to determine if a subject will respond to a bcr-abl...

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01)

Patent

CA 2707900

Methods are provided for determining if a subject of interest will respond to treatment with BCR-ABL inhibitor, comprising. The method includes quantitating expression of a plurality of genes in CD34+ cells isolated from the subject. Expression of the plurality of genes in the subject of interest is compared to a control. Altered expression of the plurality of genes in as compared to the control indicates that the subject of interest will respond to treatment with the BCR-ABL inhibitor. Arrays are also provided.

La présente invention concerne des procédés permettant de déterminer si un sujet d'intérêt réagira à un traitement avec l'inhibiteur BCR-ABL. Lesdits procédés comprennent la quantification de l'expression d'une pluralité de gènes dans des cellules CD34+ isolées du sujet. L'expression de la pluralité de gènes dans ledit sujet d'intérêt est comparée à un témoin. L'expression modifiée de la pluralité de gènes, après comparaison au témoin, indique que le sujet d'intérêt réagira au traitement avec l'inhibiteur BCR-ABL. La présente invention concerne également des matrices.

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