A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/155 (2006.01) A01N 37/18 (2006.01) C07K 14/47 (2006.01) C12N 9/02 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2455038
This application describes intracellular, cytoplasmic molecules that are translocated to the surface of a microorganism and participate in binding the microorganism to the surface of a host cell. Examples of such translocated molecules include glycerahdehyde 3-phosphate dehydrogenase, pyruvate dehydrogenase, and elongation factor-Tu. Regions oftranslocated molecules important for binding, as well as molecules which disrupt binding, are described. Antibodies directed to translocated molecules are also described.
La présente invention concerne des molécules cytoplasmiques intracellulaires transloquées à la surface d'un micro-organisme et intervenant dans la liaison du micro-organisme à la surface d'une cellule hôte. Des exemples de telles molécules transloquées comprennent une glycéraldéhyde 3-phosphate déhydrogénase, une pyruvate déhydrogénase, et un facteur Tu d'allongement. L'invention concerne également des régions de molécules transloquées importantes pour la liaison, ainsi que des molécules perturbant la liaison. Elle concerne en outre des anticorps dirigés contre des molécules transloquées.
Alvarez Rene
Baseman Joel B.
Kannan Thirumalai R.
Board Of Regents University Of Texas System
Sim & Mcburney
LandOfFree
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