Compositions and methods for modulating toll-like receptor...

Details Compositions and methods for modulating toll-like receptor... Compositions and methods for modulating toll-like receptor...

A - Human Necessities

61

K

A61K 38/17 (2006.01) A61K 31/00 (2006.01) A61P 31/00 (2006.01)

Patent

CA 2737549

The present invention relates to compositions and methods for use in the treatment of conditions such as septicaemia and septic shock. The invention further provides compositions and methods for the suppression of Toll-like Receptor 14 interaction with CD14 during Toll-like Receptor mediated signalling. The invention further provides screening assays to identify compounds which have utility in preventing the association of Toll-like Receptor 14 and CD 14.

La présente invention concerne des compositions et des procédés pour utilisation dans le traitement daffections telles que la septicémie et le choc septique. Linvention concerne en outre des compositions et des procédés pour la suppression de linteraction du récepteur Toll-like 14 avec CD14 pendant la signalisation véhiculée par le récepteur Toll-like. Linvention concerne en outre des essais de criblage pour identifier des composés qui ont une utilité dans la prévention de lassociation du récepteur Toll-like 14 et de CD14.

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