Novel naphthyridine derivatives or salts thereof

Details Novel naphthyridine derivatives or salts thereof Novel naphthyridine derivatives or salts thereof

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/435 (2006.01) A61K 31/47 (2006.01)

Patent

CA 2295309

Novel naphthyridine compounds represented by general formula (1), having antagonistic effects on tachykinin receptors, and being useful as preventives or remedies for diseases in which tachykinin receptors seemingly participate: wherein R1, R2 and R3 independently represent each hydrogen, lower alkyl, etc., or R1 and R2 or R2 and R3 may be bonded to each other to form a cyclic group; X and Y represent each methylene or ethylene; Z represents optionally substituted phenyl, etc.; A represents hydrogen, lower alkyl, etc.; and G represents acyl. A particular example of the above compounds is 2-[(-)-4- (N- benzoyl-N-methyl) amino-3-(3,4-dichlorophenyl) butyl]-10-acetylamino-1,2, 3,4- tetrahydro-benzo[b] [1,6]-naphthyridine.

On décrit de nouveaux composés de naphthyridine de la formule générale (1) qui ont des effets antagonistes sur les récepteurs de tachykinine et conviennent comme substances prophylactiques ou thérapeutiques contre des maladies auxquelles sont apparemment associés des récepteurs de tachykinine. Dans ladite formule, R?1¿, R?2¿ et R?3¿ sont chacun, indépendamment, hydrogène, alkyle inférieur, etc., ou R?1¿ et R?2¿ ou R?2¿ et R?3¿ peuvent se lier l'un à l'autre pour former un groupe cyclique; X et Y sont, chacun, méthylène ou éthylène; Z est éventuellement phényle substitué, etc.; A est hydrogène, alkyle inférieur, etc.; et G est acyle. Un exemple particulier de ces composés est 2-[(-)-4- (N-benzoyl-N-méthyl) amino-3-(3,4-dichlorophényl) butyl]-10-acétylamino-1,2, 3,4-tétrahydro-benzo[b] [1,6]-naphthyridine.

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