Methods and uses involving heme binding protein 1

Details Methods and uses involving heme binding protein 1 Methods and uses involving heme binding protein 1

G - Physics

01

N

G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2745240

The present invention relates to a method of screening for a modulator of endothelial NO synthase (eNOS) expression, a method of diagnosing a cardiovascular disease in a subject, the use of HEBP- 1 for the identification of a medicament for preventing and/or treating a disease involving eNOS dysfunction, particularly a cardiovascular disease, the use of HEBP-1 for the detection of a component of eNOS signal transduction, and the use of HEBP1 for the regulation of eNOS promoter activity.

La présente invention porte sur un procédé de dépistage pour un modulateur d'expression endothéliale NO synthase (eNOS), sur un procédé de diagnostic de maladie cardiovasculaire chez un sujet, sur l'utilisation de HEBP-1 pour l'identification d'un médicament destiné à empêcher et/ou traiter une maladie impliquant un dysfonctionnement eNOS, en particulier une maladie cardiovasculaire, sur l'utilisation de HEBP-1 pour la détection d'une composante de signal eNOS de transduction, et sur l'utilisation de HEBP1 pour la régulation d'activité du promoteur eNOS.

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