Enhanced cell-free synthesis of active proteins containing...

Details Enhanced cell-free synthesis of active proteins containing... Enhanced cell-free synthesis of active proteins containing...

C - Chemistry, Metallurgy

12

P

C12P 21/00 (2006.01) C12N 15/00 (2006.01) A61K 38/00 (2006.01) C12N 9/02 (2006.01) C12N 15/63 (2006.01)

Patent

CA 2673765

Compositions and methods are provided for the enhanced in vitro synthesis of active polypeptides containing disulfide bonds. In certain embodiments of the invention, the reaction mix includes a biological extract derived from a bacterial cell in which the glutathione reductase gene has been inactivated, which is pre-treated with a low concentration of a sulfhydryl inactivating agent.

L'invention propose des compositions et des procédés pour la synthèse in vitro améliorée de polypeptides actifs contenant des liaisons bisulfure. Dans certains modes de réalisation de l'invention, le mélange réactionnel comprend un extrait biologique dérivé d'une cellule bactérienne dans laquelle le gène glutathion réductase a été inactivé, ce qui signifie prétraité avec une faible concentration d'un agent d'inactivation au sulfhydryle.

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