Substituted piperidines as novel mdm2-p53 inhibitors

Details Substituted piperidines as novel mdm2-p53 inhibitors Substituted piperidines as novel mdm2-p53 inhibitors

C - Chemistry, Metallurgy

07

D

C07D 211/52 (2006.01) A61K 31/451 (2006.01) A61P 35/00 (2006.01) C07D 211/96 (2006.01)

Patent

CA 2516145

The present invention provides compounds having formula (II) or formula (III) and the pharmaceutically acceptable salts thereof; wherein X, n, and R1-R12 are defined herein. The invention also provides a pharmaceutical composition comprising a therapeutically effective amount of a compound represented by formula (II) or (III) and a pharmaceutically acceptable carrier or excipient. The compounds are useful for treating cancer.

L'invention concerne des composés de formule (II) ou de formule (III), ainsi que leurs sels pharmaceutiquement acceptables. X, n et R¿1?-R¿12? sont définis dans la présente. L'invention concerne également une composition pharmaceutique comprenant une quantité efficace sur le plan thérapeutique d'un composé représenté par la formule (II) ou la formule (III) et un support ou un excipient pharmaceutiquement acceptable. Lesdits composés s'utilisent dans le traitement du cancer.

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