Novel cyclooxygenase variants and methods of use

Details Novel cyclooxygenase variants and methods of use Novel cyclooxygenase variants and methods of use

C - Chemistry, Metallurgy

12

N

C12N 15/53 (2006.01) A61K 38/44 (2006.01) C07K 14/47 (2006.01) C07K 16/40 (2006.01) C12N 9/02 (2006.01) C12P 21/00 (2006.01) C12Q 1/26 (2006.01) C12Q 1/68 (2006.01) C40B 40/06 (2006.01) G01N 33/573 (2006.01)

Patent

CA 2417455

The invention relates to the isolation of novel cyclooxygenase type 1(COX-1) variant enzymes. More specifically, the invention relates to the identification of cyclooxygenase transcripts harboring inton 1, or fragment thereof, of cyclooxygenase 1. The invention further relates to the diagnosis of aberrant cyclooxygenase type 1 variant gene or gene product; the identification, production, and use of compounds which modulate cyclooxygenase type 1 variant gene expression or the activity of the cyclooxygenase type 1 variant gene product including but not limited to nucleic acid encoding cyclooxygenase type 1 variants and homologues, analogues, and deletions thereof, as well as antisense, ribozyme, triple helix, antibody, and polypeptide molecules as well as small inorganic molecules; and pharmaceutical formulations and routes of administration for such compounds.

Cette invention concerne l'isolement de nouvelles enzymes variantes de la cyclooxygénase de type 1 (COX-l). Elle concerne plus particulièrement l'identification de transcrits de cyclooxygénase contenant l'intron 1 de la cyclooxygénase 1, ou son fragment. Elle concerne également le diagnostic d'un gène ou d'un produit génétique variant aberrant de la cyclooxygénase de type 1; l'identification, la production, et l'utilisation de composés modulant l'expression du gène variant de la cyclooxygénase de type 1 ou l'activité du produit génétique variant de la cyclooxygénase de type 1, y compris, mais pas exclusivement, un acide nucléique codant les variants de la cyclooxygénase de type 1 et leurs homologues, analogues et délétions, ainsi que des molécules antisens, ribozymes, triple hélice, des molécules d'anticorps ou polypeptidiques, de même que de petites molécules inorganiques. L'invention concerne en outre des préparations pharmaceutiques et des voies d'administration de ces composés.

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