Solid dispersion comprising an active ingredient having a...

Details Solid dispersion comprising an active ingredient having a... Solid dispersion comprising an active ingredient having a...

A - Human Necessities

61

K

A61K 9/10 (2006.01)

Patent

CA 2633266

A fused solid dispersion comprising an active ingredient having a melting point of 800C or below and a pharma-ceutically acceptable absorbent having a specific surface area ranging from 20 to 400 mVg can be conveniently compressed into a tablet without generating capping and sticking problems, and a tablet comprising said fused solid dispersion can maintain an uniform release rate over a prolonged time when orally administered.

La présente invention concerne une dispersion solide fondue comprenant un ingrédient actif à point de fusion inférieur ou égal à 800 °C et un absorbant pharmaceutiquement acceptable présentant une surface spécifique comprise entre 20 et 400 mVg; ladite dispersion solide pouvant être commodément compressée sous forme de comprimé sans induire des problèmes de décalottage ou d'effet collant. Cette invention porte également sur un comprimé contenant ladite dispersion solide fondue qui peut garder une vitesse de libération uniforme sur une durée prolongée lorsqu'il est administré par voie orale.

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