A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/424 (2006.01) A61K 31/43 (2006.01) A61P 31/04 (2006.01)
Patent
CA 2610478
This invention relates to certain tricyclic 6-alkylidene penems which act as a inhibitor of class-D enzymes. .beta.-Lactamases hydrolyze .beta.-lactam antibiotics, and as such serve as the primary cause of bacterial resistance. The compounds of the present invention when combined with .beta.-lactam antibiotics will provide an effective treatment against life threatening bacterial infections. In accordance with the present invention there are provided compounds of formula I which are useful for treatment of bacterial infections having class-D enzymes associated therewith (Formula I): wherein: One of A and B denotes hydrogen and the other an optionally substituted fused tricyclic heteroaryl group; and X is S or O.
L'invention porte sur des 6-alkylidène-pénems tricycliques qui, agissant comme inhibiteurs des ß-lactamases de classe D, hydrolysent les antibiotiques de ß-lactame et, en tant que tels, sont la cause primaire de la résistance aux bactéries. Lesdits composés lorsque combinés aux antibiotiques de ß-lactame constituent un traitement efficace contre les infections bactériennes menaçant la vie. Les composés de l'invention, utiles pour le traitement d'infections bactériennes associées à des enzymes de classe D, présentent la formule (I) dans laquelle: l'un de A ou B est hydrogène, et l'autre, un groupe hétéroaryle tricyclique facultativement substitué, et X est S ou O.
Mansour Tarek Suhayl
Venkatesan Aranapakam Mudumbai
Smart & Biggar
Wyeth
LandOfFree
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