Compositions comprising the adjuvant qs-21 and polysorbate...

Details Compositions comprising the adjuvant qs-21 and polysorbate... Compositions comprising the adjuvant qs-21 and polysorbate...

A - Human Necessities

61

K

A61K 39/39 (2006.01) A61K 9/00 (2006.01)

Patent

CA 2302522

Certain novel compositions of the adjuvant saponin QS-21 having improved properties are disclosed. The compositions of the present invention are designed (1) to minimize the lytic effects of QS-21, (2) to improve the tolerance of QS-21 containing formulations in humans or other animals, (3) to stabilize the QS-21 from alkaline hydrolysis and/or (4) to maintain the high adjuvant potency of the QS-21 product. These compositions may be employed with vaccines comprising proteins or peptides, polysaccharides, lipids, or nucleic acids.

L'invention concerne de nouvelles compositions d'adjuvant de saponine QS-21 qui possèdent des propriétés améliorées. Les compositions de la présente invention sont conçues (1) pour réduire au minimum les effets lytiques de QS-21, (2) améliorer la tolérance, chez l'être humain ou l'animal, de formulations renfermant QS-21, (3) stabiliser QS-21 contre une hydrolyse alcaline et/ou (4) maintenir la forte activité adjuvante du produit de QS-21. Ces compositions peuvent être employées avec des vaccins comportant des protéines ou des peptides, des polysaccharides, des lipides ou des acides nucléiques.

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