Compositions and methods for the prevention, treatment and...

A - Human Necessities – 61 – K

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A61K 38/44 (2006.01) A01N 43/04 (2006.01) A61K 38/45 (2006.01) A61K 39/02 (2006.01) A61K 39/04 (2006.01) A61K 39/40 (2006.01) C12N 9/99 (2006.01) C12Q 1/00 (2006.01)

Patent

CA 2376723

Compositions and methods of their use for the prevention and treatment of M. tuberculosis, M. pneunomia, and other diseases related to anaerobic microorganisms are presented. These new agents inhibit their target microorganisms and represent a new class of medically active substances. Preferred embodiments indirectly or directly target the enzyme carbon monoxide dehydrogenase, which generally is found in these organisms.

La présente invention concerne des compositions et des procédés permettant leur utilisation pour la prévention et le traitement de <i>M. tuberculosis, M. pneunomia</i> et d'autres maladies liés à des micro-organismes anaérobies. Ces agents permettent l'inhibition de leurs micro-organismes cibles et représentent une nouvelle classe de substances à action médicale. Des modes de réalisation préférés de l'invention concerne directement ou indirectement l'enzyme déshydrogénase du monoxyde de carbone, que l'on peut en général trouver dans ces organismes.

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