Imidazopyridines

Details Imidazopyridines Imidazopyridines

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/435 (2006.01) A61K 31/495 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2085094

- ? - Abstract of the Disclosure Novel imidazopyridine derivatives of formula I: Image I wherein R is Image R1 is A, alkenyl or alkynyl each having up to 6 C atoms, R2 is H, COOH, COOA, CN, NO2, NHCOR5, NHSO2R5 or 1H- tetrazol-5-yl, R3 is R5-CO-alkyl, Ar-CO-alkyl, Het-CO-alkyl or Het- alkyl each having 1-6 C atoms in the "alkyl" moiety, R4, is H or Hal, R5 is alkyl having 1-6 C atoms, wherein one or more H atoms can also be replaced with F, X is absent or is -NH-CO-, -CO-NH-, -O-CH(COOH)-, -NH- CH(COOH)-, -NA-CH(COOH)-, -CH=C(COOH)-, -CH= C(CN ) - or -CH=C(1H-tetrazol-5-yl)-, Y is O or S, A is alkyl having 1-6 C atom , Ar is an unsubstituted phenyl group or a phenyl group mono~ubsti~uted~by R5, OR5, COOH, COOA, CN, NO2,. NE2, NHCOR5, NHSO2R5 or 1H-tetrazol-5-yl, Het is a five - or six -membered heteroaromatic radical having 1 to 3 N, O and/or S atoms, which can also be fused with a benzene or pyridine ring, and Hal is F, Cl, Br or I, and their salts, exhibit antagonistic properties towards angiotensin II and can be used for the treatment of - ? - hypertension, aldosteronism, cardiac insufficiency and increased intraocular pressure, and of disorders of the central nervous system.

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