Nuclear reprogramming factor

Details Nuclear reprogramming factor Nuclear reprogramming factor

C - Chemistry, Metallurgy

12

N

C12N 15/09 (2006.01) C12N 5/07 (2010.01) C12N 5/071 (2010.01) C12N 15/12 (2006.01)

Patent

CA 2632142

Disclosed is a means for inducing the reprogramming of a differentiated cell without using any embryo or ES cell and establish an inducible pluripotent stem cell having similar pluripotency and growing ability to those of an ES cell in a simple manner and with good reproductivity. As the means, a nuclear reprogramming factor for a somatic cell is provided, which comprise products of the following three genes: an Oct family gene; a Klf family gene; and an Myc family gene.

L~invention divulgue un moyen d~induire la reprogrammation d~une cellule différenciée sans utiliser aucune cellule embryonnaire ou ES et d~obtenir de manière simple et avec une bonne reproductivité une cellule-souche pluripotente inductible aux propriétés de pluripotence et de croissance semblables à celles d~une cellule ES. Le moyen fourni est un facteur de reprogrammation nucléaire d~une cellule somatique comprenant des produits des trois gènes suivants : un gène de la famille oct, un gène de la famille klf et un gène de la famille myc.

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