Condensed cyclic compounds and their use

Details Condensed cyclic compounds and their use Condensed cyclic compounds and their use

C - Chemistry, Metallurgy

07

D

C07D 281/10 (2006.01) A61K 31/55 (2006.01) C07D 223/16 (2006.01) C07D 243/04 (2006.01) C07D 243/10 (2006.01) C07D 243/12 (2006.01) C07D 243/24 (2006.01) C07D 255/04 (2006.01) C07D 267/02 (2006.01) C07D 267/14 (2006.01) C07D 267/22 (2006.01) C07D 403/12 (2006.01) C07D 413/12 (2006.01) C07D 417/02 (2006.01) C07D 417/06 (2006.01) C07D 417/12 (2006.01) C07D 471/04 (2006.01) C07D 498/04 (2006.01)

Patent

CA 2132792

Abstract of the disclosure Disclosed is a squalene synthetase inhibitor which comprises the compound represented by the formula Image wherein R1 is hydrogen or an optionally substituted hydrocarbon group; R2 is hydrogen, an optionally substituted alkyl group, an optionally substituted phenyl group or an optionally substituted aromatic heterocyclic ring group; X' is a substituent comprising an optionally esterified carboxyl group, an optionally substituted carbamoyl group, an optionally substituted hydroxyl group, an optionally substituted amino group or an optionally substituted heterocyclic radical having a protonizable hydrogen; Ring A is an optionally substituted benzene ring or an optionally substituted aromatic heterocyclic ring; Ring J' is a 7- to 8- membered heterocyclic ring containing at most three ring constituting hetero atoms; D is C or N; the Ring J' optionally having, besides R1, R2 and X', a further substituent; provided that the condensed ring composed of Ring A and ring J' is not a 2-oxo-1,2,3,5- tetrahydro-4,1-benzoxazepine ring, or a pharmaceutically acceptable salt thereof, and which is useful for the prophylaxis or therapy of hypercholesteremia or coronary sclerosis of mammals.

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