C - Chemistry – Metallurgy – 07 – J
Patent
C - Chemistry, Metallurgy
07
J
C07J 41/00 (2006.01) A61K 31/56 (2006.01) C07J 1/00 (2006.01) C07J 75/00 (2006.01)
Patent
CA 2480004
What is described is a process for making steroid crystals having a predetermined average particle size in a predetermined size range and a maximum particle size that does not exceed a predetermined maximum value, which includes subjecting a supersaturated solution containing a steroid to a wet milling by a wet milling apparatus while crystallizing, in order to obtain a primary particle suspension. Crystals obtained according to this process and pharmaceutical preparations containing them are also described.
L'invention concerne un procédé de production de cristaux de stéroïdes, dont la taille de particules moyenne se situe dans une plage prédéfinie et dont la taille de particules maximale n'excède pas une valeur prédéfinie. Ledit procédé consiste à soumettre une solution sursaturée desdits stéroïdes à un broyage humide, pendant la cristallisation, au moyen d'un dispositif de broyage humide, de manière à obtenir une suspension de grains primaires. Ladite invention concerne également des cristaux obtenus selon ce procédé ainsi que des formulations pharmaceutiques contenant ces derniers.
Eichardt Annette
Gerecke Hagen
Gliesing Sabine
Grawe Detlef
Hosel Peter
Fetherstonhaugh & Co.
Schering Aktiengesellschaft
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