C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01)
Patent
CA 2286328
A noninvasive method utilizing feces, containing sloughed colonocytes, as a sensitive technique for detecting diagnostic colonic biomarkers. By incorporating the sensitivity of semi-quantitative RT-PCR, this novel method is capable of isolating and quantitating specific eukaryotic mRNAs as candidate biomarkers in feces. In particular, measurement of the relative expression of fecal PKC .beta.II and serves as a biomarker for development of colon tumors.
On décrit une méthode non-invasive qui met en oeuvre une technique sensible utilisant des matières fécales contenant des colonocytes éboulés pour détecter des biomarqueurs coliques de diagnostic. Grâce à la sensibilité de la RT-PCR semi-quantitative qu'elle intègre, cette nouvelle méthode permet d'isoler et de quantifier des ARNm eucaryotes spécifiques en tant que biomarqueurs candidats dans des matières fécales. En particulier, le dosage de l'expression relative de la protéine kinase C .beta.¿II? et ? dans des matières fécales est utilisé comme un biomarqueur pour l'évolution de tumeurs coliques.
Chapkin Robert S.
Davidson Laurie A.
Lupton Joanne R.
Borden Ladner Gervais Llp
The Texas A. & M. University System
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