Local production and/or delivery of anti-cancer agents by...

Details Local production and/or delivery of anti-cancer agents by... Local production and/or delivery of anti-cancer agents by...

A - Human Necessities

61

K

A61K 48/00 (2006.01) A61K 35/00 (2006.01) A61K 35/12 (2006.01) A61K 38/00 (2006.01) A61K 38/19 (2006.01) A61K 38/21 (2006.01) A61K 38/22 (2006.01) A61P 35/00 (2006.01) A61P 37/02 (2006.01) C12N 5/00 (2006.01) C12N 5/06 (2006.01) C12N 5/08 (2006.01) C12N 15/63 (2006.01) C12N 15/86 (2006.01) C12N 15/864 (2006.01)

Patent

CA 2477411

The present invention concerns the use of compositions comprising, and methods for making, genetically modified mesenchymal stem cells to treat subjects with hyperproliferative disorders. Certain embodiments allow local delivery of an agent while avoiding systematic delivery of the agent alone. Stromal precursor cells may be used to produce a biological agent locally at tumour sites. The tumor microenvironment, or other proliferation inducing microenvironment, preferentially promotes the engraftment of stromal precursors as compared to other tissues.

L'invention concerne l'utilisation de compositions comprenant des cellules souches mésenchymateuses génétiquement modifiées destinées à traiter des sujets présentant des troubles hyperprolifératifs, et des procédés de production associés. Certains modes de réalisation permettent une administration locale d'un agent tout en évitant une administration systémique de l'agent seul. Des précurseurs de cellules stromales peuvent servir à produire un agent biologique localement au niveau de sites tumoraux. Le micro-environnement tumoral, ou un autre micro-environnement induisant une prolifération, favorise de préférence la prise de greffe de précurseurs de cellules stromales en comparaison avec d'autres tissus.

Affiliated with

Also associated with

Rating

Local production and/or delivery of anti-cancer agents by... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Local production and/or delivery of anti-cancer agents by..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Local production and/or delivery of anti-cancer agents by... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1600621