N-substituted hydromorphones and the use thereof

C - Chemistry – Metallurgy – 07 – D

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Details

C07D 489/02 (2006.01) A61K 31/44 (2006.01)

Patent

CA 2500118

The invention relates to N-substituted hydromorphones of Formula I or a pharmaceutically acceptable salt thereof. These compounds act as µ opioid receptor agonists. The invention is also directed to the use of compounds of Formula I for the treatment, prevention or amelioration of both acute and chronic. (see formula I)

La présente invention concerne des hydromorphones N-substituées de la formule 1 ou un sel pharmaceutiquement acceptable de ces dernières. Les composés de l'invention agissent comme agonistes du récepteur opioïde ?. L'invention se rapporte également à l'utilisation des composés de la formule 1 pour traiter, prévenir ou calmer les douleurs, tant aiguës que chroniques.

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