C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) A61K 38/00 (2006.01) C07C 271/12 (2006.01) C07C 271/20 (2006.01) C07C 271/22 (2006.01) C07C 279/12 (2006.01) C07H 19/00 (2006.01) C07H 21/00 (2006.01) C07K 5/083 (2006.01) C07K 5/09 (2006.01)
Patent
CA 2386239
The present invention relates to methods of screening for compounds that bind RNA molecules. In particular, the methods of the invention comprise screening a library of test compounds, each of which is attached to a solid support, with a dye-labeled RNA molecule to form a dye-labeled target RNA: support- attached test compound complex. By virtue of the dye label on the target RNA, the support becomes labeled and can be separated from unlabeled solid supports. The present invention further relates to methods of inhibiting an RNA-protein interaction, to methods of screening for compounds that increase or decrease the production of a protein, and to methods of screening for a compound that is capable of treating or preventing a disease whose progression is associated with an in vivo binding of a test compound to a target RNA.
La présente invention concerne des méthodes de criblage de composés qui se lient à des molécules d'ARN. Les méthodes de l'invention consistent, en particulier, à cribler une banque de composés tests, chacun étant fixé sur un support solide, à l'aide d'une molécule d'ARN marquée avec un colorant afin de former un complexe entre le composé test fixé sur support et l'ARN cible marqué avec un colorant. En raison du marquage couleur sur l'ARN cible, le support devient marqué et il est possible de séparer le supports solides marqués des supports solides non marqués. L'invention concerne aussi des méthodes permettant d'inhiber une interaction protéine-ARN, des méthodes de criblage de composés qui provoquent une augmentation ou une diminution de production d'une protéine, et des méthodes de criblage d'un composé permettant de traiter ou de prévenir une maladie dont la progression est associée à une liaison s'effectuant in vivo entre un composé test et un ARN cible.
Osler Hoskin & Harcourt Llp
University Of Medicine And Dentistry Of New Jersey
LandOfFree
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