Sustained-release preparation

Details Sustained-release preparation Sustained-release preparation

A - Human Necessities

61

K

A61K 38/05 (2006.01) A61K 9/16 (2006.01) A61K 9/52 (2006.01) A61K 31/495 (2006.01)

Patent

CA 2186709

A microcapsule containing an amorphous water- soluble 2-piperazinone-1-acetic acid compound or salt thereof and a polymer and a method of preparing said microcapsule, which comprises dispersing in an aqueous phase a dispersion of the amorphous water-soluble 2- piperazinone-1-acetic acid compound or salt thereof in a solution of a polymer in an organic solvent to give an s/o/w type emulsion and subjecting the emulsion to in-water drying. The sustained-release microcapsule which is advantageous in entrapping 2-piperazinone-1-acetic acid compound or the salt thereof as a drug in a high concentration, and in the reduced initial release of the drug, thereby reducing undesirable side effects of the drug.

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