Purified component of blue-green algae and method of use

A - Human Necessities – 61 – K

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A61K 36/02 (2006.01)

Patent

CA 2612694

Disclosed herein are extracts of blue green algae, such as Aphanizomenonflos aquae, that are enriched for a selectin ligand, such as an L-selectin ligand. Selectin ligands isolated from blue-green algae cells are disclosed herein. Methods are described for isolating these selectin ligands. The purified selectin ligands are of use in inducing stem cell mobilization in a subject. Thus, methods for inducing stem cell isolation that include administering a therapeutically effective amount of the extract enriched form the selectin ligand, or an isolated selectin ligand, are disclosed herein.

Cette invention concerne des extraits d'algues bleu-vert, comme l'algue de type Aphanizomenon flos-aquae, qui sont enrichis avec un ligand de la sélectine, tel qu'un ligand de la L-sélectine. L'invention concerne les ligands de la sélectine qui sont isolés des algues bleu-vert. Les procédés destinés à isoler les ligands de la sélectine sont également décrits. Les ligands de la sélectine purifiés sont utilisés pour induire une mobilisation des cellules souches chez un sujet. Cette invention porte donc sur des procédés visant à induire une isolation de cellules souches et comprend l'administration d'une quantité efficace d'un point de vue thérapeutique de l'extrait d'algue enrichi avec un ligand de la sélectine, ou un ligand de la sélectine isolé.

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