Quinazolin-4-one ampa antagonists

Details Quinazolin-4-one ampa antagonists Quinazolin-4-one ampa antagonists

C - Chemistry, Metallurgy

07

D

C07D 239/88 (2006.01) A61K 31/505 (2006.01) A61K 31/535 (2006.01) C07D 239/91 (2006.01) C07D 239/95 (2006.01) C07D 401/04 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/00 (2006.01) C07D 413/00 (2006.01) C07D 495/04 (2006.01)

Patent

CA 2240138

Disclosed are novel quinazolin-4-one derivatives of the formula I: (see fig. I) (wherein A is a benzo or thieno fused ring; B is phenyl, pyridyl or pyrimidyl; X is N or CH; Y-Z is CH2NH or NHCH2; R1 is H, alkyl, cyano, halo, etc.; R2 is halo, cyano, alkyl, nitro, etc.; R3 and R4 are H, alkyl, halo, etc.) and pharmaceutical compositions containing such compounds, the use of such compounds to treat neurodegenerative, psychotropic, and drug and alcohol induced central and peripheral nervous system disorders.

Divulgation concernant de nouveaux dérivés de la quinazolin-4-one de formule I (voir fig. I) (dans laquelle, A est un noyau condensé benzo ou thiéno, B est un phényle, pyridyle ou pyrimidyle; X est N ou CH; Y-Z est CH2NH ou NHCH2; R1 est un H, alkyle, cyano, halo, etc.; R2 est un halo, cyano, alkyle, nitro, etc.; R3 et R4 sont chacun un H, alkyle, halo, etc.); compositions pharmaceutiques renfermant ces dérivés, et leur emploi pour traiter les troubles de nature neurodégénérative ou psychotrope, ainsi que ceux du système nerveux central et périphérique, induits par les drogues et l'alcool.

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