The use of monomycolyl glycerol (mmg) as an adjuvant

A - Human Necessities – 61 – K

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

A61K 39/39 (2006.01) A61P 37/04 (2006.01)

Patent

CA 2691840

Here we identify MMG and its alpha- and ketomycolic acid derivatives as highly bioactive lipids derived from M. bovis BCG (Copenhagen) capable of stimulating and activating human DC's at exceedingly low doses. In addition to their direct role as immunostimulators of human DC's we demonstrate their use in the development of a new generation of adjuvants suitable for human administration. We furthermore identify a number of highly active synthetic MMG analogues with great potential in cancer treatment, and for vaccine adjuvants against both infectious disease and disorders like Alzheimers disease.

L'invention concerne le MMG identifié et ses dérivés acides alpha et cétomycoliques en tant que lipides hautement bioactifs issus du bacille de Calmette et Guérin de M. bovis (Copenhague), capables de stimuler et d'activer les DC humains à des doses excessivement faibles. En plus de leur rôle direct en tant qu'immunostimulateurs des DC humains, nous démontrons leur utilisation dans le développement d'une nouvelle génération d'adjuvants appropriés pour administration aux êtres humains. Nous identifions de plus un nombre d'analogues de MMG synthétiques hautement actifs avec un potentiel important dans le traitement du cancer, et dans des adjuvants de vaccin contre à la fois une maladie et des troubles infectieux comme la maladie d'Alzheimer.

LandOfFree

Say what you really think

Search LandOfFree.com for Canadian inventors and patents. Rate them and share your experience with other people.

Rating

The use of monomycolyl glycerol (mmg) as an adjuvant does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with The use of monomycolyl glycerol (mmg) as an adjuvant, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and The use of monomycolyl glycerol (mmg) as an adjuvant will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFCA-PAI-O-1603321

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.