Antimicrobial peptides

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/11 (2006.01) A01H 5/00 (2006.01) A01H 5/10 (2006.01) C07K 7/08 (2006.01) C12N 15/82 (2006.01)

Patent

CA 2261580

The present invention is directed to antimicrobial polypeptides and to nucleic acid molecules encoding these antimicrobial polypeptides. The polypeptide consists of from 15 to 20 amino acids and has an amphipathic alpha helix structure, wherein 3 or more of the amino acids form a positively charged domain extending axially along the alpha helix. Expression vectors, host cells, and transgenic plants, as well as methods of producing plants having improved resistance to fungal and bacterial infestation, are also provided.

Polypeptides antimicrobiens et molécules d'acide nucléique codant lesdits polypeptides. Ces derniers sont constitués de 15 à 20 acides aminés et possèdent une structure en hélice alpha amphipathique, dans laquelle 3 acides aminés ou plus forment un domaine à charge positive qui s'étend axialement le long de l'hélice alpha. Des vecteurs d'expression, des cellules hôtes et des plantes transgéniques, ainsi que des procédés de production de plantes présentant une résistance améliorée aux infestations fongiques et bactériennes sont également décrits.

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