Gene detection assay for improving the likelihood of an...

A - Human Necessities – 61 – K

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Details

A61K 39/395 (2006.01) A61K 31/335 (2006.01) A61P 35/00 (2006.01) C07K 16/32 (2006.01) G01N 33/574 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2407556

The invention provides a method for more effective treatment of patients susceptible to or diagnosed with tumors overexpressing ErbB, as determined by a gene amplification assay, with an ErbB antagonist. Such method comprises administering a cancer-treating dose of the ErbB antagonist, preferably in addition to chemotherapeutic agents, to a subject in whose tumor cells ErbB has been found to be amplified e.g., by fluorescent in situ hybridization. ErbB antagonists described include an anti-HER2 antibody. Pharmaceutical packaging for providing the components for such treatment is also provided.

L'invention concerne un procédé de traitement plus efficace de patients susceptibles d'être atteints de tumeurs surexprimant ErbB ou chez qui des tumeurs surexprimant ErbB ont été diagnostiquées, comme il a été déterminé par une analyse d'amplification de gène, avec un antagoniste d'ErbB. Un tel procédé comprend l'administration d'une dose anticancéreuse de cet antagoniste d'ErbB, de préférence en addition à des agents chimiothérapiques, à un sujet dans lequel on a découvert que l'ErbB des cellules cancéreuses a été amplifié, par ex., par hybridization fluorescente <i>in situ</i> . Les antagonistes d'ErbB décrits comprennent notamment un anticorps anti-HER2. L'invention concerne également les emballages pharmaceutiques permettant de fournir les composés servant à un tel traitement.

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