A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/5575 (2006.01) A61P 25/00 (2006.01) A61P 27/02 (2006.01)
Patent
CA 2602573
It is intended to find a novel pharmaceutical application of a prostaglandin F2.alpha. derivative. It was found that the prostaglandin F2.alpha. derivative inhibits glutamate-induced retinal neuronal cell death in a concentration- dependent manner in the retinal neuronal cell of rat fetus, in other words, the prostaglandin F2.alpha. derivative acts directly on the retinal neuronal cell and exerts a protective effect. Accordingly, the prostaglandin F2.alpha. derivative is useful in the prevention or treatment of eye diseases related to retinal neuronal cell damage.
L'invention vise à trouver une application pharmaceutique originale d~un dérivé de prostaglandine F2.alpha.. On a découvert que le dérivé de prostaglandine F2.alpha. inhibe la mort de la cellule neuronale rétinienne induite par le glutamate en fonction de la concentration dans la cellule neuronale rétinienne d~un foetus de rat, en d~autres termes, le dérivé de prostaglandine F2.alpha. agit directement sur la cellule neuronale rétinienne et exerce un effet protecteur. En conséquence, le dérivé de prostaglandine F2.alpha. est utile dans la prévention ou le traitement des maladies des yeux apparentées au dommage cellulaire neuronal rétinien.
Ishida Naruhiro
Shimazaki Atsushi
Asahi Glass Company Limited
Fetherstonhaugh & Co.
Santen Pharmaceutical Co. Ltd.
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