Bicyclopolyazamacrocyclophosphonic acids, their complexes...

Details Bicyclopolyazamacrocyclophosphonic acids, their complexes... Bicyclopolyazamacrocyclophosphonic acids, their complexes...

C - Chemistry, Metallurgy

07

F

C07F 9/6561 (2006.01) A61K 31/675 (2006.01) A61K 38/00 (2006.01) A61K 47/48 (2006.01) A61K 49/04 (2006.01) A61K 49/06 (2006.01) A61K 51/04 (2006.01) C07F 9/547 (2006.01) C07F 9/6524 (2006.01) C07F 13/00 (2006.01) C07F 15/00 (2006.01) C07K 1/13 (2006.01) C07K 14/00 (2006.01) C07K 16/00 (2006.01) C08B 37/02 (2006.01)

Patent

CA 2103556

Bicyclopolyazamacrocyclophosphonic acid compounds are disclosed which may form inert complexes with Gd, Mn or Fe ions. The overall charge of the complex can be varied to alter the in vivo biolocalization. Such complexes can be covalently att- ached to an antibody, antibody fragment or other biologically active molecule to form conjugates. The complexes and conjugates are useful as contrast agents for diagnostic purposes. Processes for the preparation of the ligand, complex and conjugate are also disclosed.

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