Method of targeting specific cell populations using...

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 16/46 (2006.01) C12N 5/077 (2010.01) A61K 31/537 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61P 31/00 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) C07D 498/18 (2006.01) C07K 16/18 (2006.01) C07K 16/30 (2006.01)

Patent

CA 2542128

The present invention discloses a method for targeting maytansinoids to a selected cell population, the method comprising contacting a cell population or tissue suspected of containing the selected cell population with a cell- binding agent maytansinoid conjugate, wherein one or more maytansinoids is covalently linked to the cell-binding agent via a non-cleavable linker and the cell-binding agent binds to cells of the selected cell population.

La présente invention se rapporte à un procédé permettant de diriger des maytansinoïdes sur une population cellulaire sélectionnée. Le procédé selon l'invention consiste à mettre une population cellulaire ou un tissu susceptible de contenir la population cellulaire sélectionnée en contact avec un conjugué formé d'un agent de liaison cellulaire et de maytansinoïdes, un ou plusieurs maytansinoïdes étant liés par covalence à l'agent de liaison cellulaire par l'intermédiaire d'un lieur non clivable, et l'agent de liaison cellulaire se liant aux cellules de la population cellulaire sélectionnée.

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