Pharmaceutical composition comprising an iron chelator

A - Human Necessities – 61 – K

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Details

A61K 9/127 (2006.01) A61K 9/00 (2006.01) A61K 9/50 (2006.01) A61K 31/198 (2006.01) A61K 31/225 (2006.01) A61P 39/04 (2006.01)

Patent

CA 2620685

The invention discloses a pharmaceutical composition for parenteral administration comprising an iron chelating agent. The active compound is at least partially in sustained release form. The preferably viscous composition may further comprise sustained release particles, such as phospholipid particles, in which active ingredient may be incorporated. The composition is particularly useful for the treatment and regeneration of nervous tissue, such as of injured nerve fibres, by intraneural or intraspinal injection.

La présente invention se rapporte à une composition pharmaceutique destinée à une administration parentérale, qui contient un chélateur du fer. Le composé actif se présente au moins partiellement sous la forme d'un composé à libération prolongée. Ladite composition, de préférence visqueuse, contient des particules à libération prolongée, telles que des particules phospholipidiques, dans lesquelles un ingrédient actif peut être incorporé. La composition selon l'invention est particulièrement utile pour traiter et régénérer des tissus nerveux, tels que des fibres nerveuses lésées, par l'intermédiaire d'une injection intraneurale ou intraspinale.

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