Therapeutic anti-melanoma compounds

Details Therapeutic anti-melanoma compounds Therapeutic anti-melanoma compounds

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) C07D 207/12 (2006.01) C07D 209/12 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 5/06 (2006.01) C12N 5/08 (2006.01)

Patent

CA 2411040

The present invention provides synthetic compounds that are crossreactive with antibodies and immune effector cells reactive with the human melanoma antigen gp100, polynucleotides that encode these compounds, and immune effector cells raised in response to presentation of these epitopes. The invention further provides methods for inducing an immune response and administering immunotherapy to a subject by delivering the compositions of the invention.

L'invention porte sur des composés de synthèse, sur des anticorps les reconnaissant et s'y fixant, sur des polypeptides codant pour ces composés, et sur des cellules effectrices immunes produites en réponse à la présentation de ces épitopes. L'invention porte également sur des méthodes d'induction d'une réponse immunitaire et sur une immunothérapie consistant à administrer à un patient la composition de l'invention.

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