A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/26 (2006.01) A61K 39/13 (2006.01) A61K 39/295 (2006.01)
Patent
CA 2564674
The present invention relates to a method of drying biological and other labile samples so that they can be preserved as a highly viscous liquid. The method involves the steps of preparing a preservation sample by dissolving/suspending an active agent in a solution of a stabilising agent, subjecting the preservation sample to such temperature and pressure conditions that the preservation sample looses solvent by evaporation without freezing or bubbling to form a foam and removing solvent until the preservation sample dries to form a highly viscous liquid. The stabilising solution comprises a glass forming polyol and a second component which decreases the flow rate of the highly viscous liquid formed by the method.
L'invention concerne une méthode de déshydratation de spécimens biologiques ou d'autres spécimens labiles, de façon à pouvoir les conserver sous forme de liquide extrêmement visqueux. Cette méthode consiste à préparer un spécimen de conservation par dissolution/suspension d'un agent actif dans une solution d'agent stabilisant, à soumettre ce spécimen de conservation à des conditions de température et de pression telles que ledit spécimen puisse perdre du solvant par évaporation sans congélation ni ébullition servant à produire une mousse, puis à extraire le solvant jusqu'à ce que ce spécimen de conservation se déshydrate sous forme de liquide extrêmement visqueux. Cette solution de stabilisation est composée d'un polyol vitrifiant et d'un deuxième constituant qui diminue le débit du liquide extrêmement visqueux obtenu au moyen de cette méthode.
Glaxosmithkline Biologicals S.a.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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