Caspase-2 inhibitors and their biological applications

Details Caspase-2 inhibitors and their biological applications Caspase-2 inhibitors and their biological applications

C - Chemistry, Metallurgy

07

K

C07K 7/06 (2006.01) A61K 38/08 (2006.01) A61P 9/10 (2006.01) C12N 9/64 (2006.01) C07K 14/81 (2006.01)

Patent

CA 2564177

The invention relates to selective new caspase-2 inhibitors that recognize caspase-2 and prevent and block its activity based on the following backbone : 2-Quinolinylcarbonyl-L-Valinyl-L-Aspartyl (methyl ester)-L-Vanilyl-L-Alaninyl- L-Aspartyl (methyl ester) 2,6-difluorophenyl ester (SEQ1) and derivatives thereof, SEQ 1 corresponding to formulae (Ia) or (Ib). Application of said inhibitors for preventing and treating diseases involving caspase-2.

La présente invention concerne de nouveaux inhibiteurs de caspase-2 qui reconnaissent la caspase-2 et préviennent et bloquent son activité, qui ont pour base le squelette suivant: 2-Quinolinylcarbonyl-<i>L</i>-Valinyl-<i>L</i>-Aspartyl (méthyl ester)-<i>L</i>-Vanilyl-<i>L</i>-Alaninyl-<i>L</i>-Aspartyl (méthyl ester) 2,6-difluorophényl ester (SEQ1) et ses dérivés, SEQ 1 correspondant aux formules (Ia) ou (Ib). L'invention concerne l'application de ces inhibiteurs pour prévenir et traiter des maladies liées à la caspase-2.

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