Lactam inhibitors of 11-beta-hydroxysteroid dehydrogenase 1

Details Lactam inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 Lactam inhibitors of 11-beta-hydroxysteroid dehydrogenase 1

C - Chemistry, Metallurgy

07

D

C07D 211/76 (2006.01) A61K 31/45 (2006.01) A61P 3/10 (2006.01) A61P 9/00 (2006.01) A61P 19/10 (2006.01) A61P 25/22 (2006.01) A61P 25/24 (2006.01) A61P 27/06 (2006.01) C07D 401/10 (2006.01)

Patent

CA 2711288

This invention relates to novel compounds of the Formula (I), (I*), (Ia), (Ib), (Ic), (Id), (Ie), (If), (If*), (Ig), (Ih), (Ij), (Ik), (111- 3), (Im1-3), (In1-3), (101-2), (Ip1-9), (Iq1-9), (Ir1-9) and (Is1-3) pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of diseases associated with the modulation or inhibition of 11.beta.-HSD1 in mammals. The invention further relates to pharmaceutical compositions of the novel compounds and methods for their use in the reduction or control of the production of cortisol in a cell or the inhibition of the conversion of cortisone to Cortisol in a cell. (I)

L'invention porte sur de nouveaux composés représentés par les formules (I), (I*), (Ia), (Ib), (Ic), (Id), (Ie), (If), (If*), (Ig), (Ih), (Ij), (Ik), (ll1-3), (Im1-3), (In1-3), (lo1-2), (Ip1-9), (Iq1-9), (Ir1-9) et (Is1-3), sur des sels pharmaceutiquement acceptables de ces composés et sur des compositions pharmaceutiques de ceux-ci, qui sont utiles pour le traitement thérapeutique de maladies associées à la modulation ou à l'inhibition de la 11ß-HSD1 chez des mammifères. L'invention porte également sur des compositions pharmaceutiques des nouveaux composés et sur des procédés pour les utiliser dans la réduction ou le contrôle de la production de Cortisol dans une cellule ou l'inhibition de la conversion de cortisone en Cortisol dans une cellule.

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