Vaccine compositions and methods useful in inducing immune...

Details Vaccine compositions and methods useful in inducing immune... Vaccine compositions and methods useful in inducing immune...

A - Human Necessities

61

K

A61K 39/00 (2006.01) A61K 31/70 (2006.01) A61K 39/02 (2006.01) A61K 48/00 (2006.01) C07K 14/245 (2006.01) C07K 14/74 (2006.01) C12Q 1/68 (2006.01) G01N 33/564 (2006.01)

Patent

CA 2247804

Vaccine compositions useful in inducing immune protection in a host against arthritogenic peptides involved in the pathogenesis of rheumatoid arthritis are disclosed. Each vaccine composition provides antigenic dnaJp1 peptide (by including the peptide or a polynucleotide which encodes the peptide) and, optionally, other peptide fragments of the microbial dnaJ protein and/or human homologs thereof. Methods for identifying persons who are predisposed to develop rheumatoid arthritis and methods for use of the inventive vaccines are also disclosed.

L'invention concerne des compositions de vaccins utiles pour induire chez un hôte une protection immunitaire contre les peptides arthritogènes impliqués dans la pathogénèse de la polyarthrite rhumatoïde. Chaque composition de vaccin comporte un peptide dnaJp1 antigénique (par inclusion du peptide ou d'un polynucléotide codant pour le peptide) et, éventuellement, d'autres fragments peptidiques de la protéine dnaJ microbienne et/ou ses homologues humains. L'invention concerne également des méthodes permettant d'identifier les personnes prédisposées à la polyarthrite rhumatoïde, ainsi que des méthodes permettant d'utiliser les vaccins de l'invention.

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