Screening method

Details Screening method Screening method

G - Physics

01

N

G01N 33/68 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2397273

The invention relates to methods for the identification of novel receptors and/or novel ligands. The invention is based on the concept that parasites have developed a number of biologically-active compounds in their saliva to cope with the defence mechanisms of the host organisms on which they feed and to manipulate the biological functions of host molecules to their advantage. These saliva compounds can be used to identify novel molecules within the host systems. Furthermore, these saliva compounds can be used to elucidate the functions of molecules whose existence is already known.

L'invention concerne des procédés servant à identifier de nouveaux récepteurs et/ou de nouveaux ligands. Elle est basée sur le fait que des parasites ont développé un certain nombre de composés biologiquement actifs dans leur salive afin de s'adapter aux mécanismes de défense des organismes hôtes sur lesquels ils se nourrissent et de manipuler les fonctions biologiques des molécules hôtes à leur avantage. On peut utiliser ces composés contenus dans la salive afin d'identifier de nouvelles molécules à l'intérieur de ces systèmes hôtes. On peut, de plus, utiliser ces composés dans le but de clarifier les fonctions de molécules dont l'existence est déjà connue.

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