Compositions, methods and devices for the transdermal...

Details Compositions, methods and devices for the transdermal... Compositions, methods and devices for the transdermal...

A - Human Necessities

61

K

A61K 47/36 (2006.01) A61F 6/06 (2006.01) A61K 9/06 (2006.01) A61K 9/14 (2006.01) A61K 9/70 (2006.01) A61K 31/56 (2006.01) A61K 31/57 (2006.01) A61K 45/08 (2006.01) A61K 47/38 (2006.01) A61K 47/44 (2006.01) A61M 35/00 (2006.01) A61K 47/02 (2006.01) A61K 47/14 (2006.01) A61K 47/26 (2006.01)

Patent

CA 2256365

The present invention is directed to compositions, and methods for the delivery of drugs. Devices for the transdermal delivery of drugs are also provided. Specifically, the present invention relates to hydrogel compositions comprising water and a base mixture, in which the base mixture comprises: (i) a gelling agent consisting of methylcellulose or at least one natural gum, or a mixture thereof; (ii) at least one natural gum; (iii) glucose; (iv) propylparaben; (v) methyl paraben; and (vi) sodium chloride. The compositions may further comprise pectin, glycolic, alcoholic or oil-based additives, a coloring, fragrance, or other pharmaceutically acceptable additive. The compositions may further comprise substituted ureas of the formula R-NH-CO-NH2 such as butylurea. The compositions may further comprise drugs such as hormones selected from progesterone, progestin, estrogen and testosterone. Methods for the treatment of disorders responsive to hormone therapy are also provided. The figure is a cross-sectional view of a membrane-moderated transdermal drug delivery system.

L'invention concerne des compositions et des procédés d'administration de médicaments. Les dispositifs d'administration transdermique de médicaments sont également décrits. En particulier, l'invention concerne des compositions hydrogel comprenant de l'eau et un mélange de base, ce mélange de base consistant en: (i) un agent gélifiant consistant en de la méthylcellulose ou au moins en une gomme naturelle, ou un mélange de ceux-ci; (ii) au moins une gomme naturelle; (iii) du glucose; (iv) du propylparabène; (v) du méthylparabène; et (vi) du chlorure de sodium. Les compositions peuvent comprendre également de la pectine, des additifs glycoliques, alcooliques ou à base d'huile, un colorant, un agent parfumant ou un autre additif acceptable sur le plan pharmaceutique. Les compositions peuvent également comprendre des urées substituées ayant la formule R-NH-CO-NH¿2?, telle que la butylurée. Les compositions peuvent également comprendre des médicaments tels que des hormones choisies parmi la progestérone, la progestine, l'oestrogène et la stétostérone. Des procédés de traitement de troubles à l'aide d'une thérapie hormonale sont également décrits. La figure est une vue en coupe d'un système d'administration transdermique de médicaments à régulation par membrane.

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