Methods and compositions for the treatment of cancer

A - Human Necessities – 61 – K

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A61K 36/534 (2006.01) A61K 31/35 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2756452

Isolated compounds and combinations of isolated compounds isolated from Scutellaria barbata D. Don are effec-tive in the generation of reactive oxygen species, induction of DNA damage and induction of apoptosis in cancer cells. The com-pounds and combinations may be prepared as pharmaceutical compositions for administration to mammals, such as humans, for the treatment of solid cancers, such as epithelial cancers. Such epithelial cancers include breast cancer and ovarian cancers.

L'invention concerne des composés isolés et des combinaisons de composés isolés issus de Scutellaria barbata D. Don, qui sont efficaces pour produire des espèces à oxygène réactif, induire des dommages sur l'ADN et induire une apoptose dans les cellules cancéreuses. Les composés et les combinaisons peuvent être préparés sous forme de compositions pharmaceutiques pour administration à des mammifères, comme les humains, pour le traitement de cancers solides, comme les cancers épithéliaux. Ces cancers épithéliaux comprennent le cancer du sein et les cancers de l'ovaire.

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